APA has specific guidelines for the use of italics. You can find them in APA 7, Section 6.22. As a general rule, use italics sparingly.
According to the manual, italics are appropriate for:
The Publication Manual of the American Psychological Association is…
In the show Friends, Rachel and Ross…
The American Journal of Psychology includes…
The term zone of proximal development means....
Adolescents labeled high risk should...
Scores ranged from 0 (never) to 5 (continuously)
n = 5
LL, MSE (see list on p. 120 of the sixth edition APA manual)
Italics are inappropriate for:
Use reverse italics when a word or phrase is italicized within a title or other phrase that is already italicized. Reverse italics means that the word or phrase that would normally be italicized is not italicized (presented in plain text).
In Gone With the Wind: Is it America’s Strangest Film?, Barber (2014) expressed puzzlement at the film classic’s ongoing popularity.
In this example, the title of the film Gone With the Wind is in reverse italics as part of the webpage title in which it appears.